1. Stem Cell/Wnt
  2. Wnt

Wnt

The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three Wnt signaling pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the protein Dishevelled inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, the noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell, and the noncanonical Wnt/calcium pathway regulates calcium inside the cell. The clinical importance of Wnt signaling pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes.

Wnt 相关产品 (33):

Cat. No. Product Name Effect Purity
  • HY-14428
    ICG-001 Inhibitor 99.69%
    ICG-001是β-catenin/TCF介导的转录抑制剂。 它特异性结合 CREB 蛋白起作用,IC50 为3 μM。
  • HY-15597
    Salinomycin Inhibitor >98.0%
    Salinomycin是具有强大的抗菌 (anti-bacterial) 活性的抗球虫药,和靶向人类癌症干细胞的新型抗癌剂。
  • HY-12238
    IWR-1 Inhibitor 99.83%
    IWR-1是端锚聚合酶抑制剂,抑制Wnt/β-catenin信号传导途径。
  • HY-15659
    Wnt-C59 Inhibitor 99.56%
    Wnt-C59 (C59)是高效可口服的 PORCN 抑制剂,IC50 为 74 pM。
  • HY-A0293
    Pyrvinium pamoate Inhibitor >98.0%
    Pyrvinium pamoate是FDA批准的抗蠕虫药物,抑制 WNT 通路信号传导。
  • HY-101275
    EMT inhibitor-1 Inhibitor 98.71%
    EMT inhibitor-1 是 HippoTGF-βWnt 信号通路的抑制剂,并拥有抗肿瘤活性。
  • HY-75342
    Methyl vanillate Activator >98.0%
    Methyl vanillate 是枳椇属植物中的提取物,是Wnt/β-catenin信号通路活化剂。苯甲酸酯,是香草酸的甲酯。它具有抗氧化作用。植物代谢物。
  • HY-17577
    Berberine chloride hydrate Activator 99.56%
    Berberine chloride hydrate是从一些植物中提取的生物碱,具有多种生物功能,包括胰岛素敏化,抗炎和抗氧化活性。它是 AMPK 的活化剂。
  • HY-19987
    BML-284 Activator 99.98%
    BML-284是选择性和可渗透细胞的Wnt信号传导激活剂。
  • HY-18988
    ETC-159 Inhibitor 98.67%
    ETC-159是有效的,具有口服活性的 PORCN 抑制剂。抑制β-catenin报告基因活性的 IC50 值为2.9 nM。
  • HY-101916
    Heparan Sulfate
    Heparan sulfate是一种复杂的线性多糖。它作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞表面和细胞外基质中表达丰富。
  • HY-13912
    IWP-2 Inhibitor
    IWP-2 抑制 Wnt 加工和分泌,IC50 为 27 nM。
  • HY-101090
    KYA1797K Inhibitor >98.0%
    KYA1797K是有效,选择性的 Wnt/β-catenin 抑制剂,IC50 值为0.75 µM。
  • HY-15721
    FH535 Inhibitor 99.93%
    FH535 是 Wnt/β-cateninPPAR 的抑制剂,具有抗肿瘤活性。
  • HY-101085
    SKL2001 Agonist 98.08%
    SKL2001 是 Wnt/β-catenin 信号通路的激动剂,具有抗肿瘤活性。
  • HY-12681
    CCT251545 Inhibitor 99.34%
    CCT251545是一种口服生物有效的WNT抑制剂, IC50值为5 nM。
  • HY-100830
    NCB-0846 Inhibitor 98.27%
    NCB-0846是具有口服活性的TNIK抑制剂,IC50值为21 nM。
  • HY-16665
    iCRT 14 Inhibitor 98.90%
    iCRT 14 是一种 β-连环蛋白应答转录(CRT)抑制剂,能够抑制 Wnt 信号通路,IC50 值为 40.3 nM。
  • HY-N0400
    Wogonin Inhibitor 99.83%
    Wogonin 是一种天然黄酮类物质,能够抑制 CDK8 and Wnt 的活性,具有抗炎、抗肿瘤等功效。
  • HY-19739
    JW74 Antagonist 99.45%
    JW74 拮抗 LiCl 诱导的经典 Wnt 信号传导的激活,IC50 为 420 nM。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

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