1. Membrane Transporter/Ion Channel
  2. Potassium Channel

Potassium Channel

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel 相关产品 (91):

Cat. No. Product Name Effect Purity
  • HY-100381
    Nigericin sodium salt Activator >98.0%
    Nigericin sodium salt 是从吸水链霉菌中得到的一种抗生素,作为 H+,K+ 和 Pb2+ 离子载体起作用。
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride是D25HT2A钾通道钠通道的拮抗剂。 Chlorpromazine与 D2 和 5HT2A 结合的 Ki 分别为363 nM和8.3 nM。
  • HY-50694
    Senicapoc Inhibitor 99.83%
    Senicapoc (ICA-17043) 是有效,选择性的 Gardos 通道 阻断剂,IC50 为11 nM。 它阻断来自人红细胞的Ca2+诱导的铷通量,IC50 值为11 nM, 抑制红细胞脱水的 IC50 为30 nM。
  • HY-15206
    Glibenclamide Inhibitor >98.0%
    Glibenclamide(Glyburide)是磺酰脲类化合物,能调节胰岛素的产生。
  • HY-B0604
    4-Aminopyridine Inhibitor 99.97%
    4-Aminopyridine是非选择性钾离子通道阻断剂,能从细胞质侧与靶点结合。
  • HY-14290A
    Pinacidil monohydrate >99.0%
    Pinacidil monohydrate,一种抗高血压药,是一种钾通道激活剂。
  • HY-110110
    VU0463271 Inhibitor
    VU0463271 是神经特异性氯钾协同转运蛋白 2 (KCC2) 的有效抑制剂,其 IC50 值为 61 nM。
  • HY-15551
    E-4031 Inhibitor 98.03%
    E-4031是III类抗心律失常药,选择性地阻断hERG钾通道
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 是红参的主要成分。Ginsenoside Rg3 抑制 Na+hKv1.4 通道,IC50 分别为 32.2±4.5 和 32.6±2.2 μM。Ginsenoside Rg3 还抑制 NF-κB 活性和 COX-2 表达。
  • HY-B0401
    Tolbutamide Inhibitor >98.0%
    Tolbutamide是第一代钾离子通道阻断剂,是磺酰脲类口服活性的降糖化合物。
  • HY-B0232
    Dofetilide Inhibitor >98.0%
    Dofetilide(Tikosyn)是III型抗心律失常药,能阻断钾离子通道。
  • HY-13519
    TRAM-34 Inhibitor 99.71%
    TRAM-34 是一种选择性的钙激活 K+ 通道 (IKCa1)阻断剂,Kd 为 20 nM。
  • HY-B1140
    Diazoxide Activator 99.99%
    Diazoxide是一种ATP敏感性的钾离子通道激活剂; 可用于治疗高胰岛素血症。
  • HY-10015
    PAP-1 Inhibitor 99.69%
    PAP-1是Kv1.3电压门控的钾离子通道抑制剂,能抑制人效应记忆T细胞增殖,EC50为2 nM。
  • HY-B0112
    Minoxidil Activator 99.84%
    Minoxidil(U 10858)是血管扩张剂,可做用于高血压和脱发。
  • HY-14188
    Amiodarone hydrochloride Inhibitor 99.82%
    Amiodarone is a lipophilic antiarrhythmic/antianginal drug which is able to influence the physicochemical status of biological lipid components.
  • HY-B1221
    Flufenamic acid Activator 99.92%
    Flufenamic acid 是一种非甾体类抗炎剂,能够抑制 COX 的活性,激活 AMPK 的活性,调节离子通道,阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca2+ channel),调节非选择性阳离子通道,激活钾离子通道 (K+ channel) 等。
  • HY-17001
    Flupirtine Maleate Activator 99.97%
    Flupirtine (D 9998)马来酸盐是神经元钾通道开放剂,同时具有NMDA受体拮抗剂特性。
  • HY-12496
    NS-1619 Activator 99.30%
    NS-1619是 Ca2_addition_-activated K_addition_-channel选择性激动剂。
  • HY-D0143
    Quinine Inhibitor 99.59%
    Quinine 是一种抗疟药, 也是钾通道的抑制剂其 IC50 值为 169 μM。
Isoform Specific Products

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