1. NF-κB
  2. MALT1


MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp。 MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL。 MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL。 MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma。 MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors。

MALT1 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-12276
    MI 2 Inhibitor 99.56%
    MI 2 (MALT1 inhibitor) 是一种不可逆的 MALT1 蛋白酶抑制剂,IC50 为 5.84 μM。
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