1. Protein Tyrosine Kinase/RTK
  2. Btk


Bruton tyrosine kinase (Btk) is a member of the Tec family kinases with a well-characterized role in B-cell antigen receptor (BCR)-signaling and B-cell activation.

Btk plays a crucial role in B cell development and activation through the BCR signaling pathway and represents a new target for diseases characterized by inappropriate B cell activity. Btk is a kinase expressed exclusively in B cells and myeloid cells and has a well characterized, vital role in B cells highlighted by the human primary immune deficiency disease, X-linked agammaglobulinemia (XLA), which results from mutation in the Btk gene. Btk plays an essential role in the BCR signaling pathway. Antigen binding to the BCR results in B cell receptor oligomerization, Syk and Lyn kinase activation, followed by Btk kinase activation. Once activated, Btk forms a signaling complex with proteins such as BLNK, Lyn, and Syk and phosphorylates phospholipase C (PLC)γ2. This leads to downstream release of intracellular Ca2+ stores and propagation of the BCR signaling pathway through extracellular signal-regulated kinase and NF-κB signaling, ultimately resulting in transcriptional changes to foster B cell survival, proliferation, and/or differentiation.

Btk 相关产品 (36):

Cat. No. Product Name Effect Purity
  • HY-10997
    Ibrutinib Inhibitor 99.89%
    Ibrutinib (PCI-32765) 是选择性,不可逆的 Btk 抑制剂,IC50 值为 0.5 nM。
  • HY-17600
    Acalabrutinib Inhibitor 99.86%
    Acalabrutinib 是一种新颖的,有效的,选择性的 BTK 抑制剂,在体内试验中 IC50EC50 分别为 3 nM 和 8 nM。
  • HY-19834
    Fenebrutinib Inhibitor 99.50%
    Fenebrutinib (GDC-0853) 是有效,选择性和非共价的布鲁顿酪氨酸激酶 (Btk) 抑制剂,Ki 为0.91 nM。
  • HY-101215
    Evobrutinib Inhibitor 98.17%
    Evobrutinib是 BTK 的抑制剂, 来自专利US20140162983 化合物实例0174。
  • HY-100342
    Ibrutinib-biotin Inhibitor 99.67%
    Ibrutinib-biotin 是一种由 Ibrutinib 通过长链接头连接到生物素上组成的探针,具体可参考 WO2014059368A1 中 Compound 1-5,抑制 BTKIC50 值为 0.755-1.02 nM。
  • HY-112166
    PRN1008 Inhibitor 99.49%
    PRN1008 是布鲁顿氏酪氨酸激酶 (BTK) 可逆的、共价抑制剂,其 IC50 值为 1.3 nM。
  • HY-100335
    PCI-33380 Inhibitor 98.33%
    PCI-33380 是布鲁顿酪氨酸激酶 (BTK) 的不可逆抑制剂(荧光探针)。
  • HY-15771
    Tirabrutinib Inhibitor 99.31%
    Tirabrutinib (ONO-4059) 是高选择性,可口服的 BTK 抑制剂, IC50 为2.2 nM。
  • HY-18012
    Spebrutinib Inhibitor 99.95%
    Spebrutinib (AVL-292; CC-292) 是共价,高选择性和口服活性的 Btk 抑制剂,IC50 为0.5 nM。
  • HY-101474
    (±)-Zanubrutinib Inhibitor 99.70%
    (±)-Zanubrutinib 是一种有效的选择性 Bruton's 酪氨酸激酶 (Btk) 抑制剂。
  • HY-101474A
    Zanubrutinib Inhibitor 99.45%
    Zanubrutinib 是一个选择性的 Bruton tyrosine kinase (BTK) 抑制剂。
  • HY-80002
    BMX-IN-1 Inhibitor 98.88%
    BMX-IN-1是BMX 激酶IC50 值为8.0 nM。
  • HY-15427
    GDC-0834 Inhibitor 99.07%
    GDC-0834 是一种有效的选择性 BTK 抑制剂。GDC-0834 抑制 BTK,在体外酶实验和细胞实验中,IC50 分别为 5.9 和 6.4 nM,而在小鼠和大鼠体内,IC50 分别为 1.1 和 5.6 μM。
  • HY-101941
    BTK IN-1 Inhibitor 98.88%
    BTK IN-1 是一种有效的 BTK 抑制剂,IC50 值 <100 nM。
  • HY-109078
    Vecabrutinib Inhibitor 99.96%
    Vecabrutinib 是一种有效的,非共价的 BTKITK 抑制剂,Kd 值分别为 0.3 nM 和 2.2 nM;Vecabrutinib 对 ITK 的 IC50 值为 24 nM。
  • HY-18018
    RN486 Inhibitor 99.38%
    RN486是高活性Btk抑制剂,IC50为4.0 nM。
  • HY-15771A
    Tirabrutinib hydrochloride Inhibitor 98.74%
    Tirabrutinib (ONO-4059) hydrochloride 的 IC50 值是2.2 nm,是一种有选择性和新颖的抑制剂。 在B细胞中ONO-4058结合BTK,因此阻止B细胞受体信号和阻碍B细胞的发展。
  • HY-18009
    LFM-A13 Inhibitor 99.70%
    LFM-A13 是一种有效的 BTKJAK2PLK 抑制剂,可抑制 BTK,Plx1 和 PLK3 的活性,IC50 分别为 2.5 μM,10 μM 和 61 μM。
  • HY-11999
    CGI-1746 Inhibitor
    CGI-1746 是一种有效的,高选择性的 Btk 抑制剂,IC50 值为 1.9 nM。
  • HY-112161
    BMS-986195 Inhibitor 98.78%
    BMS-986195 是一个有效的、布鲁顿氏酪氨酸激酶 (BTK) 的不可逆共价抑制剂,其 IC50 值 <1 nM。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

大有彩票 完美彩票 博乐彩票 完美彩票 完美彩票 同城彩票 天娱彩票 王者彩票 完美彩票 大有彩票