1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase

Aurora Kinase

Aurora kinases are serine/threonine kinases that are essential for cell proliferation. Aurora kinase helps the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. Three Aurora kinases have been identified in mammalian cells to date, Aurora A, Aurora B, Aurora C. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers. The human Aurora kinases present a similar domain organization, with a N-terminal domain of 39 to 129 residues in length, a protein kinase domain and a short C-terminal domain containing 15 to 20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during protein-protein interactions.

Aurora Kinase Isoform Specific Products:

  • Aurora A

  • Aurora B

  • Aurora C

Aurora Kinase 相关产品 (36):

Cat. No. Product Name Effect Purity
  • HY-10971
    Alisertib Inhibitor 99.43%
    Alisertib (MLN 8237)是选择性的 Aurora A 抑制剂,IC50为1.2 nM。
  • HY-10161
    Tozasertib Inhibitor 99.85%
    Tozasertib 是 Aurora A/B/C 激酶抑制剂,Ki 值分别为 0.6,18,4.6 nM。
  • HY-50514
    AT9283 Inhibitor 99.13%
    AT9283是一种多靶点激酶抑制剂,有效抑制极光激酶A/BJAK2/3 (IC50=1.2 nM, 1.1 nM)。
  • HY-10126
    Barasertib-HQPA Inhibitor 99.64%
    AZD1152-HQPA是一种高度选择性的极光激酶B抑制剂,在非细胞试验中 IC50 值为0.37 nM。AZD1152-HQPA对Aurora B 的选择性是Aurora A的3700倍。
  • HY-10179
    Danusertib Inhibitor 99.44%
    Danusertib 是一种极光激酶 (aurora kinase) 抑制剂,能够抑制 Aurora A,Aurora B 和 Aurora C 的活性,IC50 值分别为 13,79 和 61 nM。
  • HY-18161
    CCT241736 Inhibitor 99.86%
    CCT241736 是一种有效的,可口服的 FLT3Aurora kinase 双重抑制剂,能够有效抑制 Aurora-A (Kd,7.5 nM;IC50,38 nM),Aurora-B (Kd,48 nM),FLT3 (Kd,6.2 nM),以及 FLT3 突变体 FLT3-ITD (Kd,38 nM) 和 FLT3(D835Y) (Kd,14 nM) 的活性。
  • HY-114258
    LY3295668 Inhibitor
    LY3295668 是高度特异性的激光激酶 A (AurA) 的抑制剂,其对 AurA 和 AurB 的Ki 值分别为 0.8 nM 和 1038 nM。
  • HY-111506
    Aurora inhibitor 1 Inhibitor
    Aurora inhibitor 1 是一种有效的 Aurora 抑制剂,抑制 Aurora AAurora B 激酶的 IC50 分别 ≤4 nM 和 ≤13 nM。
  • HY-12054
    Hesperadin Inhibitor 98.48%
    Hesperadin是ATP竞争型的极光激酶 (aurora B) 抑制剂,IC50值为250 nM。
  • HY-14711
    Reversine Inhibitor 99.25%
    Reversine 是一种ATP-竞争性的 Aurora kinase 抑制剂,作用于 Aurora AAurora BAurora CIC50 分别为 400,500 和 400 nM。
  • HY-10127
    AZD1152 Inhibitor 98.95%
    AZD1152 是 Barasertib-hQPA 的前体药物,是高度选择性的 Aurora B 抑制剂,IC50 值为 0.37 nM。
  • HY-70044
    GSK-1070916 Inhibitor 99.55%
    GSK-1070916是有效,选择性,ATP竞争型的极光激酶B/C (aurora B/C) 抑制剂,Ki 值分别为0.38和1.5 nM。
  • HY-10180
    MLN8054 Inhibitor >98.0%
    MLN8054是高效,选择性,有口服活性的极光激酶 (aurora A) 抑制剂,IC50 值为4 nM。
  • HY-10339
    KW-2449 Inhibitor 99.85%
    KW-2449是多靶点激酶抑制剂,对FLT3ABLABLT315IAurora kinaseIC50 值分别为6.6,14,4 和 48 nM.
  • HY-13253
    AMG 900 Inhibitor 98.19%
    AMG 900 是一种有效的选择性的 pan-Aurora 激酶抑制剂,作用于 Aurora ABCIC50 分别为 5 nM,4 nM 和 1 nM。
  • HY-15767
    TAK-632 Inhibitor 99.13%
    TAK-632 是一种有效的 pan-RAF 抑制剂,作用于 CRAFBRAFV600EBRAFWTIC50 分别为 1.4,2.4 和 8.3 nM。
  • HY-12201
    TAK-901 Inhibitor 99.80%
    TAK-901是多靶点的的极光激酶 (aurora)抑制剂,对极光激酶A和B的IC50 值分别为21 和15 nM。
  • HY-10329
    JNJ-7706621 Inhibitor 98.80%
    JNJ-7706621 是一种有效的 aurora kinase 抑制剂,同时能有效抑制 CDK1CDK2,对 CDK1,CDK2,Aurora-A 和 Aurora-B 的 IC50 值分别为 9,3,11 和 15 nM。
  • HY-12003
    SNS-314 Inhibitor 99.81%
    SNS-314有效,选择性的极光激酶 (aurora) 抑制剂,对极光激酶A,B,C的IC50 值分别为9,31 和6 nM。
  • HY-13252
    MK-5108 Inhibitor 98.62%
    MK-5108是高效和特异性的Aurora-A激酶抑制剂,IC50值为0.064 nM。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

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