LR-90 

目录号: HY-76383
产品使用指南

LR-90 是晚期糖基化终产物 (advanced glycation end product (AGE)) 抑制剂,能够抑制人单核细胞的炎症反应。LR-90 也可用于糖尿病动物模型研究。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

LR-90 Chemical Structure

LR-90 Chemical Structure

CAS No. : 245075-84-7

1.  客户无需承担相应的运输费用。

2。  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥3903 In-stock
5 mg ¥2500 In-stock
10 mg ¥4500 In-stock
50 mg ¥12500 In-stock
100 mg ¥19500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 技术信息

  • 纯度 & 产品资料

  • 参考文献

Description

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes[1]. LR-90 is also used in the research of diabetic animal model[2].

IC50 & Target

AGE[1]

In Vitro

LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours[1].
LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours[1].
LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells[1].

Cell Viability Assay[1]

Cell Line: THP-1 cells
Concentration: 0, 25, 50, 100, and 200 μM
Incubation Time: 24 hours
Result: Showed no cytotoxicity to THP-1 cells.

RT-PCR[1]

Cell Line: THP-1 cells
Concentration: 0, 25, 50, 100, and 200 μM
Incubation Time: One hour before S100b addition for 4 hours.
Result: Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b.
In Vivo

LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats[2].
LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation[2].

Animal Model: Male ZDF rats (13 to 40 weeks)[2]
Dosage: 50 mg/L
Administration: P.O. for 27 weeks
Result: Significantly reduced plasma triacylglycerol and cholesterol by ∼55% and ∼30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4093 mL 7.0465 mL 14.0930 mL
5 mM 0.2819 mL 1.4093 mL 2.8186 mL
10 mM 0.1409 mL 0.7047 mL 1.4093 mL
*Please refer to the solubility information to select the appropriate solvent。
References
  • [1].

    [2].

Molecular Weight

709.57

Formula

C₃₅H₃₄Cl₂N₄O₈

CAS No.

245075-84-7

SMILES

O=C(NC1=CC=C(C=C1)OC(C)(C)C(O)=O)NC(C(Cl)=C2)=CC=C2CC3=CC=C(C(Cl)=C3)NC(NC4=CC=C(C=C4)OC(C)(C)C(O)=O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • [1]。

    [2]。

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
LR-90
目录号:
HY-76383
需求量:

LR-90

Cat。 No。: HY-76383

同城彩票 完美彩票 天娱彩票 大有彩票 博乐彩票 新火彩票 完美彩票 王者彩票 博乐彩票 完美彩票