1. DNA Methyltransferase

CM-579 

目录号: HY-117421
产品使用指南

CM-579 是第一代可逆的,G9a 和DNA 甲基转移酶 (DNMT) 的双抑制剂,其IC50 值分别为 16 nM 和32 nM。在多种癌细胞中发挥有效活性作用。

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CM-579 Chemical Structure

CM-579 Chemical Structure

CAS No. : 1846570-40-8

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Description

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].

IC50 & Target[1]

DNA Methyltransferase

32 nM (IC50)

DNMT1

1.5 nM (Kd)

DNMT3A

92 nM (IC50)

DNMT3B

1000 nM (IC50)

G9a

16 nM (IC50)

In Vitro

The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0298 mL 10.1492 mL 20.2984 mL
5 mM 0.4060 mL 2.0298 mL 4.0597 mL
10 mM 0.2030 mL 1.0149 mL 2.0298 mL
*Please refer to the solubility information to select the appropriate solvent。
References
  • [1].

Molecular Weight

492。65

Formula

C₂₉H₄₀N₄O₃

CAS No.

1846570-40-8

SMILES

CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • [1].

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
CM-579
目录号:
HY-117421
需求量:

CM-579

Cat. No.: HY-117421

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